概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFG KKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSG LTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVH GLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEG FEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMH HSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIG YSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQE MNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLS GGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAP LICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDY SVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAA LKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICN NPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKL KRKELRNHYLKDIERMYGGK
    • 分子量
      101 kDa including tags
    • 氨基酸
      1 to 670

技术指标

Our Abpromise guarantee covers the use of ab152375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ACS 4
    • ACS4
    • ACSL 4
    • Acsl4
    • ACSL4_HUMAN
    • acyl CoA synthetase 4
    • Acyl CoA synthetase long chain family member 4
    • FACL 4
    • FACL4
    • Fatty acid Coenzyme A ligase
    • fatty acid Coenzyme A ligase long-chain 4
    • LACS 4
    • LACS4
    • Lignoceroyl CoA synthase
    • Long chain 4
    • long chain acyl CoA synthetase 4
    • long chain fatty acid CoA ligase 4
    • long chain fatty acid Coenzyme A ligase 4
    • Long-chain acyl-CoA synthetase 4
    • Long-chain-fatty-acid--CoA ligase 4
    • MRX63
    • MRX68
    see all
  • 功能
    Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
  • 疾病相关
    Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
    Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis.
  • 序列相似性
    Belongs to the ATP-dependent AMP-binding enzyme family.
  • 细胞定位
    Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152375 stained with Coomassie Blue.

文献

ab152375 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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