Recombinant人EYA2 protein (ab124581)

概述

  • 产品名称Recombinant人EYA2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO00167
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSMERVFVW DLDETIIIFH SLLTGTFASR YGKDTTTSVR IGLMMEEMIF NLADTHLFFN DLEDCDQIHV DDVSSDDNGQ DLSTYNFSAD GFHSSAPAAN LCLGSGVHGG VDWMRKLAFR YRRVKEMYNT YKNNVGGLIG TPKRETWLQL RAELEALTDL WLTHSLKALN LINSRPNCVN VLVTTTQLIP ALAKVLLYGL GSVFPIENIY SATKTGKESC FERIMQRFGR KAVYVVIGDG VEEEQGAKKH NMPFWRISCH ADLEALRHAL ELEYL
    • 分子量33 kDa including tags
    • 氨基酸244 to 514
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab123581 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride

常规信息

  • 别名
    • EAB 1
    • EAB1
    • EYA 2
    • EYA2
    • EYA2_HUMAN
    • eyes absent 2 homolog (Drosophila)
    • Eyes absent homolog 2
    • Eyes absent homolog 2 (Drosophila)
    • Translation of this uORF probably lowers the translation efficiency of EYA2
    see all
  • 功能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
  • 组织特异性Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
  • 序列相似性Belongs to the HAD-like hydrolase superfamily. EYA family.
  • 发展阶段At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human EYA2 protein 图像

  • 15% SDS-PAGE showing ab124581 (3µg).

Recombinant Human EYA2 protein (ab124581)参考文献

ab124581 has not yet been referenced specifically in any publications.

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