重组人EXOSC10蛋白(ab152619)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKAS GGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDR SKVTELEDKFDLLVDANDVILERVGILLDEASGVNKNQQPVLPAGLQVPK TVVSSWNRKAAEYGKKAKSETFRLLHAKNIIRPQLKFREKIDNSNTPFLP KIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADFIHQQRTQQVE QDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMY ILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGR HSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDK MRLEMWERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKK HLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQG IIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTT CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLG HRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAR EQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLK ISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGK KCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR
    • 分子量
      127 kDa including tags
    • 氨基酸
      1 to 885
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab152619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Autoantigen PM/Scl 2
    • Exosc10
    • Exosome component 10
    • EXOSX_HUMAN
    • P100 polymyositis scleroderma overlap syndrome associated autoantigen
    • P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
    • p2
    • p3
    • p4
    • PM Scl
    • PM/Scl 100
    • PM/Scl-100
    • PMSCL
    • PMSCL2
    • Polymyositis/scleroderma autoantigen 100 kDa
    • Polymyositis/scleroderma autoantigen 2
    • Polymyositis/scleroderma autoantigen 2 100 kDa
    • RRP6
    • Rrp6p
    see all
  • 功能
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.
  • 序列相似性
    Contains 1 3'-5' exonuclease domain.
    Contains 1 HRDC domain.
  • 细胞定位
    Cytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152619 stained with Coomassie Blue.

文献

ab152619 has not yet been referenced specifically in any publications.

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