Recombinant人ETHE1 protein (ab119454)

概述

  • 产品名称Recombinant人ETHE1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO95571
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMLSQRG GSGAPILLRQ MFEPVSCTFT YLLGDRESRE AVLIDPVLET APRDAQLIKE LGLRLLYAVN THCHADHITG SGLLRSLLPG CQSVISRLSG AQADLHIEDG DSIRFGRFAL ETRASPGHTP GCVTFVLNDH SMAFTGDALL IRGCGRTDFQ QGCAKTLYHS VHEKIFTLPG DCLIYPAHDY HGFTVSTVEE ERTLNPRLTL SCEEFVKIMG NLNLPKPQQI DFAVPANMRC GVQTPTA
    • 分子量29 kDa including tags
    • 氨基酸13 to 254
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab119454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Ethe1
    • ETHE1 protein, mitochondrial precursor
    • ETHE1_HUMAN
    • ethylmalonic encephalopathy 1
    • Ethylmalonic encephalopathy protein 1
    • hepatoma subtracted clone one
    • Hepatoma subtracted clone one protein
    • HSCO
    • mitochondrial
    • Protein ETHE1
    • Protein ETHE1 mitochondrial
    • YF13H12
    see all
  • 功能Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) [MIM:602473]. EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.
  • 序列相似性Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • 细胞定位Cytoplasm. Nucleus. Mitochondrion matrix. According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
  • Information by UniProt

Recombinant Human ETHE1 protein 图像

  • 15% SDS-PAGE analysis of ab119454 (3µg)

Recombinant Human ETHE1 protein (ab119454)参考文献

ab119454 has not yet been referenced specifically in any publications.

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