The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
E74 like factor 3
E74 like factor 3 ets domain transcription factor
E74 like factor 3 ets domain transcription factor epithelial specific
E74 like factor 3 ETS domain transcription factor serine box epithelial specific
E74-like factor 3
Epithelial restricted with serine box
Epithelial-restricted with serine box
Epithelium restricted Ets protein ESX
Epithelium specific Ets factor 1
Epithelium specific Ets transcription factor 1
Epithelium-restricted Ets protein ESX
Epithelium-specific Ets transcription factor 1
Ets domain transcription factor serine box
Ets domain transcription factor serine box epithelial specific
Ets transcription factor
ETS-related transcription factor Elf-3
功能Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
组织特异性Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
序列相似性Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.
结构域the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
细胞定位Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.