This product is an active protein and may elicit a biological response in vivo, handle with caution.
Extracellular Signal Regulated Kinase 1
Extracellular signal related kinase 1
Extracellular signal-regulated kinase 1
Insulin Stimulated MAP2 Kinase
Insulin-stimulated MAP2 kinase
MAP kinase 1
MAP kinase 3
MAP kinase isoform p44
Microtubule Associated Protein 2 Kinase
Microtubule-associated protein 2 kinase
Mitogen Activated Protein Kinase 3
Mitogen-activated protein kinase 1
Mitogen-activated protein kinase 3
Protein Kinase Mitogen Activated 3
功能Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
翻译后修饰Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-204.