Recombinant人ERK1 protein (ab90409)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab90409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab90409 is inactive
  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab90409 is purified by Ni-agarose chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 1mM DTT, pH 8.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • ERK
    • ERK 1
    • ERK-1
    • ERK1
    • ERT 2
    • ERT2
    • Extracellular Signal Regulated Kinase 1
    • Extracellular signal related kinase 1
    • Extracellular signal-regulated kinase 1
    • HGNC6877
    • HS44KDAP
    • HUMKER1A
    • Insulin Stimulated MAP2 Kinase
    • Insulin-stimulated MAP2 kinase
    • MAP Kinase
    • MAP kinase 1
    • MAP kinase 3
    • MAP kinase isoform p44
    • MAPK
    • MAPK 1
    • MAPK 3
    • MAPK1
    • Mapk3
    • MGC20180
    • Microtubule Associated Protein 2 Kinase
    • Microtubule-associated protein 2 kinase
    • Mitogen Activated Protein Kinase 3
    • Mitogen-activated protein kinase 1
    • Mitogen-activated protein kinase 3
    • MK03_HUMAN
    • OTTHUMP00000174538
    • OTTHUMP00000174541
    • p44 ERK1
    • p44 MAPK
    • p44-ERK1
    • p44-MAPK
    • P44ERK1
    • P44MAPK
    • PRKM 3
    • PRKM3
    • Protein Kinase Mitogen Activated 3
    see all
  • 功能Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻译后修饰Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-204.
  • Information by UniProt

Recombinant human ERK1 protein (ab90409)参考文献

ab90409 has not yet been referenced specifically in any publications.

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