Recombinant人ERG protein (ab112284)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP11308
    • 种属Human
    • 序列MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPR VPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPD TV
    • 分子量37 kDa including tags
    • 氨基酸1 to 100
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112284 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    Western blot

    SDS-PAGE

    ELISA

    Peptide Array

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

常规信息

  • 别名
    • Avian erythroblastosis virus E-26 (v-ets) oncogene related
    • D030036I24Rik
    • Erg
    • Erg 3
    • ERG/EWS fusion gene, included
    • ERG/FUS fusion gene, included
    • ERG/TMPSSR2 fusion gene, included
    • ERG_HUMAN
    • ERG1, included
    • ERG2, included
    • ets related
    • ETS-related gene
    • KCNH2
    • Oncogene ERG
    • p55
    • TMPRSS2/ERG fusion
    • Transcriptional regulator ERG
    • transcriptional regulator ERG (transforming protein ERG)
    • Transforming protein ERG
    • v ets avian erythroblastosis virus E26 oncogene
    • v ets avian erythroblastosis virus E26 oncogene related
    • v ets erythroblastosis virus E26 oncogene homolog
    • v ets erythroblastosis virus E26 oncogene like
    • v ets erythroblastosis virus E26 oncogene like isoform 2
    • v-ets erythroblastosis virus E26 oncogene
    • v-ets erythroblastosis virus E26 oncogene homolog (avian)
    • V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e
    see all
  • 功能Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
  • 疾病相关Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.
    Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.
  • 序列相似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • 细胞定位Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt

Recombinant Human ERG protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue with recombinant protein.

Recombinant Human ERG protein (ab112284)参考文献

ab112284 has not yet been referenced specifically in any publications.

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