Recombinant人ERCC1 protein (ab83630)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab83630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

常规信息

  • 别名
    • COFS 4
    • COFS4
    • DNA excision repair protein ERCC 1
    • DNA excision repair protein ERCC-1
    • DNA excision repair protein ERCC1
    • ERCC 1
    • ERCC1
    • ERCC1_HUMAN
    • Excision repair cross complementation group 1
    • Excision repair cross complementing 1
    • Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1
    • Excision repair protein
    • RAD 10
    • RAD10
    • UV 20
    • UV20
    see all
  • 功能Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
  • 疾病相关Defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4 (COFS4) [MIM:610758]. COFS is a degenerative autosomal recessive disorder of prenatal onset affecting the brain, eye and spinal cord. After birth, it leads to brain atrophy, hypoplasia of the corpus callosum, hypotonia, cataracts, microcornea, optic atrophy, progressive joint contractures and growth failure. Facial dysmorphism is a constant feature. Abnormalities of the skull, eyes, limbs, heart and kidney also occur.
  • 序列相似性Belongs to the ERCC1/RAD10/SWI10 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human ERCC1 protein (ab83630)参考文献

ab83630 has not yet been referenced specifically in any publications.

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