The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00 Constituents: 0.32% Tris HCl, 10% Glycerol, 2.4% Urea
EPH related receptor tyrosine kinase ligand 1
EPH-related receptor tyrosine kinase ligand 1
Ephrin-A1, secreted form
Immediate early response protein B61
Ligand of eph related kinase 1
TNF alpha-induced protein 4
Tumor necrosis factor alpha induced protein 4
Tumor necrosis factor alpha-induced protein 4
功能Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
组织特异性Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
序列相似性Belongs to the ephrin family.
翻译后修饰Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.