The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Erythrocyte membrane protein band 4.2
Erythrocyte protein 4.2
Erythrocyte surface protein band 4.2
功能Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
疾病相关Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
序列相似性Belongs to the transglutaminase superfamily. Transglutaminase family.
翻译后修饰Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
细胞定位Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.