Recombinant人EPB42 protein (ab114956)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP16452-2
    • 种属Human
    • 序列KMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSV WPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTVVAPELSA
    • 分子量37 kDa including tags
    • 氨基酸623 to 721

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技术指标

Our Abpromise guarantee covers the use of ab114956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • EPB42
    • EPB42_HUMAN
    • Erythrocyte membrane protein band 4.2
    • Erythrocyte protein 4.2
    • Erythrocyte surface protein band 4.2
    • MGC116735
    • MGC116737
    • P4.2
    • PA
    • SPH5
    see all
  • 功能Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
  • 疾病相关Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
  • 序列相似性Belongs to the transglutaminase superfamily. Transglutaminase family.
  • 翻译后修饰Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
  • 细胞定位Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
  • Information by UniProt

Recombinant Human EPB42 protein 图像

  • 12.5% SDS-PAGE showing ab114956 at approximately 36.52kDa.
    Stained with Coomassie Blue.

Recombinant Human EPB42 protein (ab114956)参考文献

ab114956 has not yet been referenced specifically in any publications.

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