Recombinant人Endostatin protein (ab73653)

概述

描述

  • 性质
    Recombinant
  • 来源
    Pichia pastoris
  • 氨基酸序列
    • 种属
      Human
    • 序列
      Amino Acid Composition is in total agreement with the expected amino acid composition of native human Endostatin.

技术指标

Our Abpromise guarantee covers the use of ab73653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab73653 is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Alpha 1 collagen type 18 (XVIII)(COL18A1)
    • Alpha 1 type XVIII collagen
    • Antiangiogenic agent
    • COIA1_HUMAN
    • COL15A1
    • Col18a1
    • Collagen alpha 1(XV) chain
    • Collagen alpha 1(XVIII) chain
    • Collagen alpha-1(XV) chain
    • Collagen type XV proteoglycan
    • Collagen type XVIII alpha 1
    • Collagen XV, alpha 1 polypeptide
    • Collagen, type XV, alpha 1
    • Endostatin
    • Endostatin XV
    • FLJ27325
    • FLJ34914
    • FLJ38566
    • KNO
    • KNO1
    • KS
    • MGC74745
    • Multi functional protein MFP
    • OTTHUMP00000021782
    • OTTHUMP00000115472
    • OTTHUMP00000115473
    see all
  • 功能
    COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • 组织特异性
    Present in multiple organs with highest levels in liver, lung and kidney.
  • 疾病相关
    Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • 序列相似性
    Belongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • 翻译后修饰
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

文献

ab73653 has not yet been referenced specifically in any publications.

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