The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
% SDS-PAGE. ab73653 is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Alpha 1 collagen type 18 (XVIII)(COL18A1)
Alpha 1 type XVIII collagen
Collagen alpha 1(XV) chain
Collagen alpha 1(XVIII) chain
Collagen alpha-1(XV) chain
Collagen type XV proteoglycan
Collagen type XVIII alpha 1
Collagen XV, alpha 1 polypeptide
Collagen, type XV, alpha 1
Multi functional protein MFP
功能COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
组织特异性Present in multiple organs with highest levels in liver, lung and kidney.
疾病相关Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
序列相似性Belongs to the multiplexin collagen family. Contains 1 FZ (frizzled) domain. Contains 1 TSP N-terminal (TSPN) domain.
翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
细胞定位Secreted > extracellular space > extracellular matrix.