Recombinant人Endostatin protein (ab56290)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK

技术指标

Our Abpromise guarantee covers the use of ab56290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

    Western blot

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.
    Purity : Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Alpha 1 collagen type 18 (XVIII)(COL18A1)
    • Alpha 1 type XVIII collagen
    • Antiangiogenic agent
    • COIA1_HUMAN
    • COL15A1
    • Col18a1
    • Collagen alpha 1(XV) chain
    • Collagen alpha 1(XVIII) chain
    • Collagen alpha-1(XV) chain
    • Collagen type XV proteoglycan
    • Collagen type XVIII alpha 1
    • Collagen XV, alpha 1 polypeptide
    • Collagen, type XV, alpha 1
    • Endostatin
    • Endostatin XV
    • FLJ27325
    • FLJ34914
    • FLJ38566
    • KNO
    • KNO1
    • KS
    • MGC74745
    • Multi functional protein MFP
    • OTTHUMP00000021782
    • OTTHUMP00000115472
    • OTTHUMP00000115473
    see all
  • 功能COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • 组织特异性Present in multiple organs with highest levels in liver, lung and kidney.
  • 疾病相关Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • 序列相似性Belongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant human Endostatin protein 图像

  • All lanes : Anti-Endostatin antibody (Biotin) (ab84250) at 0.2 µg/ml

    Lane 1 : Recombinant human Endostatin protein (ab56290) at 0.1 µg
    Lane 2 : Recombinant human Endostatin protein (ab56290) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

Recombinant human Endostatin protein (ab56290)参考文献

ab56290 has not yet been referenced specifically in any publications.

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