Recombinant人Emerin protein (ab112283)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP50402
    • 种属Human
    • 分子量54 kDa including tags
    • 氨基酸1 to 254

技术指标

Our Abpromise guarantee covers the use of ab112283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    Western blot

    ELISA

    Peptide Array

    SDS-PAGE

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

常规信息

  • 别名
    • EDMD
    • Emd
    • EMD_HUMAN
    • Emerin
    • Emery Dreifuss muscular dystrophy
    • STA
    see all
  • 功能Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
  • 组织特异性Skeletal muscle, heart, colon, testis, ovary and pancreas.
  • 疾病相关Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
  • 序列相似性Contains 1 LEM domain.
  • 翻译后修饰Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
  • 细胞定位Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
  • Information by UniProt

Recombinant Human Emerin protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue with proprietary tag.

Recombinant Human Emerin protein (ab112283)参考文献

ab112283 has not yet been referenced specifically in any publications.

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