重组人Emerin蛋白(ab112283)
Key features and details
- Expression system: Wheat germ
- Suitable for: WB, ELISA, PepArr, SDS-PAGE
描述
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产品名称
重组人Emerin蛋白 -
生物活性
useful for Antibody Production and Protein Array -
表达系统
Wheat germ -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
预测分子量
54 kDa including tags -
氨基酸
1 to 254
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab112283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Western blot
ELISA
Peptide Array
SDS-PAGE
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形式
Liquid -
补充说明
This product is useful for Antibody Production and Protein Array.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
Reduced glutathione
常规信息
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别名
- EDMD
- Emd
- EMD_HUMAN
see all -
功能
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. -
组织特异性
Skeletal muscle, heart, colon, testis, ovary and pancreas. -
疾病相关
Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects. -
序列相似性
Contains 1 LEM domain. -
翻译后修饰
Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle. -
细胞定位
Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab112283 尚未被引用在任何文献中。