Recombinant人EMAP II protein (ab101823)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ12904
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMLPAVAVSEPVVLRFMIFCRLLAKMANNDA VLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLK KEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVS SGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLD LRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRM VILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAF PGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTM SNSGIK
    • 分子量39 kDa including tags
    • 氨基酸1 to 336
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab101823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 85 % SDS-PAGE.
    ab101823 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • AIMP 1
    • Aimp1
    • AIMP1/p43
    • AIMP1_HUMAN
    • Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
    • ARS interacting multifunctional protein 1
    • EMAP 2
    • EMAP-2
    • EMAP-II
    • EMAP2
    • EMAPII
    • Endothelial monocyte activating polypeptide
    • Endothelial monocyte activating polypeptide 2
    • Endothelial monocyte-activating polypeptide 2
    • Endothelial monocyte-activating polypeptide II
    • HLD3
    • Multisynthase complex auxiliary component p43
    • Multisynthetase complex auxiliary component p43
    • OTTHUMP00000219673
    • p43
    • Scye 1
    • Scye1
    • Scye1, formerly
    • Small inducible cytokine subfamily E member 1
    • Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
    • Small inducible cytokine subfamily E, member 1, formerly
    see all
  • 功能Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
  • 疾病相关Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:260600]. A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.
  • 序列相似性Contains 1 tRNA-binding domain.
  • 翻译后修饰Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Cytoplasmic vesicle > secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
  • Information by UniProt

Recombinant Human EMAP II protein 图像

  • 15% SDS-PAGE analysis of ab101823 (3µg)

Recombinant Human EMAP II protein (ab101823)参考文献

ab101823 has not yet been referenced specifically in any publications.

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