Recombinant人ELK1 protein (ab70380)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab70380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • ELK 1
    • Elk1
    • ELK1 member of ETS oncogene family
    • ELK1 protein
    • ELK1_HUMAN
    • ELK2 member of ETS oncogene family
    • ETS domain containing protein Elk 1
    • ETS domain containing protein Elk1
    • ETS domain protein Elk1
    • ETS domain-containing protein Elk-1
    • ETS like gene 1
    • Member of ETS oncogene family
    • Oncogene Elk1
    • Tyrosine kinase (ELK1) oncogene
    see all
  • 功能Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.
  • 组织特异性Lung and testis.
  • 序列相似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
  • 翻译后修饰Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
    On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human ELK1 protein 图像

  • SDS-PAGE showing ELK1 at approximately 81kDa.

Recombinant Human ELK1 protein (ab70380)参考文献

ab70380 has not yet been referenced specifically in any publications.

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