Recombinant人ELAVL4 protein (ab114734)

概述

  • 产品名称Recombinant人ELAVL4 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP26378
    • 种属Human
    • 序列VLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGY RLGDRVLQVSFKTNKAHKS
    • 分子量33 kDa including tags
    • 氨基酸312 to 380

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技术指标

Our Abpromise guarantee covers the use of ab114734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ELAV (embryonic lethal abnormal vision Drosophila) like 4
    • ELAV L4
    • ELAV like 4
    • ELAV like protein 4
    • ELAV-like protein 4
    • ELAV4_HUMAN
    • Elavl4
    • Embryonic lethal abnormal vision Drosophila homolog of like 4
    • Hu antigen D
    • Hu-antigen D
    • HuD
    • Paraneoplastic encephalomyelitis antigen HuD
    • PNEM
    see all
  • 功能May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.
  • 组织特异性Brain.
  • 序列相似性Belongs to the RRM elav family.
    Contains 3 RRM (RNA recognition motif) domains.
  • 翻译后修饰Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth.
  • Information by UniProt

Recombinant Human ELAVL4 protein 图像

  • 12.5% SDS-PAGE showing ab114734 at approximately 33.22kDa.
    Stained with Coomassie Blue.

Recombinant Human ELAVL4 protein (ab114734)参考文献

ab114734 has not yet been referenced specifically in any publications.

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