Recombinant人eIF5A2 protein (ab117664)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMADEIDFTTGDAGASSTYPMQCSALRKNGF VVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMD VPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAG EDVQVSVMCAMSEEYAVAIKPCK
    • 分子量
      19 kDa including tags
    • 氨基酸
      1 to 153
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 85 % SDS-PAGE.
    ab117664 is purified by proprietary chromatographic techniques. Purity is greater than 85.0% as determined by SDS-PAGE.
  • 形式
    Liquid
  • 补充说明
    Although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

常规信息

  • 别名
    • 9630038B20
    • eIF 5A 2
    • eIF 5A2
    • eIF-4D
    • eIF-5A-2
    • eIF-5A2
    • EIF5A 2
    • EIF5A2
    • eIF5AII
    • Eukaryotic initiation factor 5A isoform 2
    • Eukaryotic translation initiation factor 5A-2
    • Eukaryotic translation initiation factor 5A2
    • IF5A2_HUMAN
    see all
  • 功能
    mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
  • 组织特异性
    Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
  • 序列相似性
    Belongs to the eIF-5A family.
  • 翻译后修饰
    eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 细胞定位
    Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt

文献

ab117664 has not yet been referenced specifically in any publications.

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