Recombinant人eIF5A protein (ab91910)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGK HGHA KVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGY LSLLQDSGEV REDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAA VAIKAMAK
    • 氨基酸1 to 154

技术指标

Our Abpromise guarantee covers the use of ab91910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 形式Lyophilised
  • 补充说明Protein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Thiourea, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 复溶Reconstitute with 67 µl aqua dest.

常规信息

  • 别名
    • eIF 4D
    • EIF 5A
    • eIF 5A 1
    • eIF 5A1
    • eIF-4D
    • eIF-5A
    • eIF-5A-1
    • eIF-5A1
    • eIF4D
    • eif5a
    • EIF5A1
    • eIF5AI
    • Eukaryotic initiation factor 5A
    • Eukaryotic initiation factor 5A isoform 1
    • Eukaryotic translation initiation factor 5A
    • Eukaryotic translation initiation factor 5A 1
    • Eukaryotic translation initiation factor 5A-1
    • IF5A1_HUMAN
    • MGC104255
    • MGC99547
    • Rev binding factor
    • Rev-binding factor
    • uORF
    • uORF A
    see all
  • 功能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
  • 组织特异性Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
  • 序列相似性Belongs to the eIF-5A family.
  • 翻译后修饰eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 细胞定位Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt

Recombinant Human eIF5A protein 图像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

Recombinant Human eIF5A protein (ab91910)参考文献

ab91910 has not yet been referenced specifically in any publications.

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