Recombinant人EFEMP1 protein (ab114651)

概述

  • 产品名称Recombinant人EFEMP1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ12805
    • 种属Human
    • 序列MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVGQQCKDIDECDI VPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTG VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIP SNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ CPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNY TCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC WNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSI RSDRSVPSDIFQIQATTIYANTINTFRIKSGSENGEFYLRQTSPVSAMLV LVKSLSGPREHIVDLEMLTASSIGTFRTSSVLRLTIIVGPFSF
    • 分子量80 kDa including tags
    • 氨基酸1 to 493

技术指标

Our Abpromise guarantee covers the use of ab114651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DHRD
    • Doyne honeycomb retinal degeneration
    • DRAD
    • EFEMP 1
    • EFEMP1
    • EGF containing fibulin like extracellular matrix protein 1
    • EGF containing fibulin like extracellular matrix protein 1 precursor
    • EGF-containing fibulin-like extracellular matrix protein 1
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1
    • Extracellular protein S1 5
    • Extracellular protein S1-5
    • FBLN 3
    • FBLN3
    • FBLN3_HUMAN
    • FBNL
    • FIBL 3
    • FIBL-3
    • FIBL3
    • Fibrillin like
    • Fibrillin like protein
    • Fibrillin-like protein
    • FIBULIN 3
    • Fibulin-3
    • Fibulin3
    • FLJ35535
    • Heat shock 70 KD protein 1
    • MGC111353
    • MLVT
    • MTLV
    • S1 5
    • T16 protein
    see all
  • 功能Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • 组织特异性In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • 疾病相关Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • 序列相似性Belongs to the fibulin family.
    Contains 6 EGF-like domains.
  • 细胞定位Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt

Recombinant Human EFEMP1 protein 图像

  • 12.5% SDS-PAGE showing ab114651 at approximately 79.97kDa stained with Coomassie Blue.

Recombinant Human EFEMP1 protein (ab114651)参考文献

ab114651 has not yet been referenced specifically in any publications.

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