Recombinant人EED protein (ab112381)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO75530
    • 种属Human
    • 序列KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
    • 分子量37 kDa including tags
    • 氨基酸342 to 441

技术指标

Our Abpromise guarantee covers the use of ab112381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Useful for Antibody Production and Protein Array
  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明ab112381 is best used within three months from the date of receipt.Useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • eed
    • EED protein
    • EED, mouse, homolog of
    • EED_HUMAN
    • Embryonic ectoderm development
    • Embryonic ectoderm development isoform a
    • Embryonic ECTODERM development protein homolog
    • Embryonic ectoderm development protein, mouse, homolog of
    • hEED
    • OTTHUMP00000235483
    • OTTHUMP00000235484
    • OTTHUMP00000235485
    • Polycomb protein eed
    • WAIT 1
    • WAIT-1
    • WAIT1
    • WD protein associating with integrin cytoplasmic tails 1
    see all
  • 功能Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
  • 组织特异性Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
  • 序列相似性Belongs to the WD repeat ESC family.
    Contains 7 WD repeats.
  • 发展阶段Expression peaks at the G1/S phase boundary.
  • 细胞定位Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.
  • Information by UniProt

Recombinant Human EED protein 图像

  • ab112381 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human EED protein (ab112381)参考文献

ab112381 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"