The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性Useful for Antibody Production and Protein Array
补充说明ab112381 is best used within three months from the date of receipt.Useful for Antibody Production and Protein Array
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
EED, mouse, homolog of
Embryonic ectoderm development
Embryonic ectoderm development isoform a
Embryonic ECTODERM development protein homolog
Embryonic ectoderm development protein, mouse, homolog of
Polycomb protein eed
WD protein associating with integrin cytoplasmic tails 1
功能Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
组织特异性Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
序列相似性Belongs to the WD repeat ESC family. Contains 7 WD repeats.
发展阶段Expression peaks at the G1/S phase boundary.
细胞定位Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.