Recombinant人EBP50 protein (ab112385)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO14745
    • 种属Human
    • 序列MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEK AGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQ KLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQREL RPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIV EVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEH LNGPL
    • 分子量66 kDa including tags
    • 氨基酸1 to 358

技术指标

Our Abpromise guarantee covers the use of ab112385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明ab112385 is best used within three months from the date of receipt.Useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • EBP 50
    • EBP50
    • Ezrin radixin moesin binding phosphoprotein 50
    • Ezrin-radixin-moesin-binding phosphoprotein 50
    • Na(+)/H(+) exchange regulatory cofactor NHE RF
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    • Na+/H+ exchange regulatory co factor
    • NHERF
    • NHERF 1
    • NHERF-1
    • NHERF1
    • NHRF1_HUMAN
    • NPHLOP2
    • Regulatory cofactor of Na(+)/H(+) exchanger
    • Slc9a3r1
    • Sodium hydrogen exchanger regulatory factor 1
    • Sodium-hydrogen exchanger regulatory factor 1
    • Sodium/hydrogen exchanger regulatory factor 1
    • Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1
    • Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform A3 regulatory factor 1
    • Solute carrier family 9 member 3 regulator 1
    see all
  • 功能Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
  • 组织特异性Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
  • 疾病相关Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).
  • 序列相似性Contains 2 PDZ (DHR) domains.
  • 翻译后修饰Phosphorylated on serine residues.
  • 细胞定位Cytoplasm. Apical cell membrane. Endomembrane system. Cell projection > filopodium. Cell projection > ruffle. Cell projection > microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.
  • Information by UniProt

Recombinant Human EBP50 protein 图像

  • ab112385 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human EBP50 protein (ab112385)参考文献

ab112385 has not yet been referenced specifically in any publications.

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