H.sapiens mRNA for novel T cell activation protein
Microtubule associated protein RP/EB family member 2
Microtubule-associated protein RP/EB family member 2
T cell activation protein EB1 family
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
Belongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1 EB1 C-terminal domain.
Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Cytoplasm > cytoskeleton. Associated with the microtubule network. Accumulates at the plus end of microtubules.