Recombinant人DYRK2 protein (ab79734)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab79734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 200 µM ATP, 0.01% Brij-35, and 2 µM substrate (SER/THR 9) at room temperature for 1 hour.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 1810038L18Rik
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2
    • Dual specificity tyrosine phosphorylation regulated kinase 2
    • Dual specificity tyrosine-phosphorylation-regulated kinase 2
    • DYRK2
    • DYRK2_HUMAN
    • EC 2.7.12.1
    • FLJ21217
    • FLJ21365
    see all
  • 功能
    Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
  • 组织特异性
    Testis, after the onset of spermatogenesis.
  • 序列相似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Phosphorylated on serine/threonine residues.
  • 细胞定位
    Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
  • Information by UniProt

图片

  • SDS-PAGE showing ab79734 at approximately 63.5kDa (4µg).

文献

ab79734 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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