Recombinant人DYRK1A protein (ab114522)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ13627
    • 种属Human
    • 序列NQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFS ANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVAS
    • 分子量36 kDa including tags
    • 氨基酸674 to 763

技术指标

Our Abpromise guarantee covers the use of ab114522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Dual specificity tyrosine phosphorylation regulated kinase
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A
    • Dual specificity tyrosine phosphorylation regulated kinase 1
    • Dual specificity tyrosine phosphorylation regulated kinase 1A
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1A
    • Dual specificity YAK 1 related kinase
    • Dual specificity YAK1 related kinase
    • Dual specificity YAK1-related kinase
    • DYR1A_HUMAN
    • DYRK
    • DYRK 1
    • DYRK 1A
    • DYRK1
    • Dyrk1a
    • DYRKA
    • hMNB
    • HP 86
    • HP86
    • Minibrain (Drosophila) homolog
    • Minibrain homolog
    • Minibrain, Drosophila, homolog of
    • MNB
    • MNB protein kinase
    • Mnb protein kinase homolog hp86
    • MNB protein kinase, Serine/threonine-specific
    • MNB/DYRK protein kinase
    • MNBH
    • MRD7
    • OTTHUMP00000109090
    • OTTHUMP00000109091
    • OTTHUMP00000109094
    • OTTHUMP00000174799
    • Protein kinase minibrain homolog
    • Serine/threonine kinase MNB
    see all
  • 功能May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
  • 组织特异性Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
  • 疾病相关Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • 发展阶段Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.
  • 结构域The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028).
  • 翻译后修饰Autophosphorylated on tyrosine residues.
  • 细胞定位Nucleus speckle.
  • Information by UniProt

Recombinant Human DYRK1A protein 图像

  • 12.5% SDS-PAGE analysis of Human DYRK1A protein (ab114522). Stained with Coomassie Blue.

Recombinant Human DYRK1A protein (ab114522)参考文献

ab114522 has not yet been referenced specifically in any publications.

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Thank you for contacting us.

I can confirm the protein ab114522 is exactly the immunising peptide for ab54944 and could therefore serve as a positive control.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"