Recombinant人DYNLL1 protein (ab101204)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMCDRKAVIKNADMSEEMQQDSVECATQALE KYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQ VAILLFKSG
    • 分子量
      13 kDa including tags
    • 氨基酸
      1 to 89
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab101204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    purified by using conventional chromatography techniques
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: 0% None
    Constituents: 10% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • 8 kDa dynein light chain
    • 8kDLC
    • Cytoplasmic dynein light polypeptide
    • DLC1
    • DLC8
    • DNCL1
    • DNCLC1
    • DYL1_HUMAN
    • Dynein , cytoplasmic, light chain 1
    • Dynein light chain 1 cytoplasmic
    • Dynein light chain 1, cytoplasmic
    • Dynein light chain LC8 type 1
    • Dynein light chain LC8-type 1
    • Dynein, cytoplasmic, light polypeptide 1
    • Dynein, light chain, LC8-type 1
    • DYNLL1
    • HDLC1
    • LC8
    • LC8a
    • MGC126137
    • MGC126138
    • MGC72986
    • PIN
    • Protein inhibitor of neuronal nitric oxide synthase
    • Protein inhibitor of neuronal NOS
    see all
  • 功能
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
    Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
    Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the dynein light chain family.
  • 翻译后修饰
    Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • 细胞定位
    Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
  • Information by UniProt

图片

  • ab101204 at 3 µg analysed by 15% SDS PAGE.

文献

ab101204 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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