Recombinant人Dscam protein (ab116817)

概述

  • 产品名称Recombinant人Dscam protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO60469
    • 种属Human
    • 序列KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDH RKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF
    • 分子量35 kDa including tags
    • 氨基酸184 to 271

技术指标

Our Abpromise guarantee covers the use of ab116817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • CHD2
    • CHD2 42
    • CHD2 52
    • Down syndrome cell adhesion molecule
    • DSCAM
    • DSCAM_HUMAN
    • human CHD2-52 down syndrome cell adhesion molecule 2, 9
    • OTTHUMP00000109193 2
    • SD11109p
    see all
  • 功能Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
  • 组织特异性Primarily expressed in brain.
  • 序列相似性Contains 6 fibronectin type-III domains.
    Contains 10 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC.
  • 翻译后修饰Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
  • 细胞定位Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
  • Information by UniProt

Recombinant Human Dscam protein 图像

  • 12.5% SDS-PAGE showing ab116817 at approximately 35.31kDa.
    Stained with Coomassie Blue.

Recombinant Human Dscam protein (ab116817)参考文献

ab116817 has not yet been referenced specifically in any publications.

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