Recombinant人DR4 protein (ab641)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN
    • 分子量
      23 kDa

技术指标

Our Abpromise guarantee covers the use of ab641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 内毒素水平
    < 0.100 Eu/µg
  • 形式
    Lyophilised
  • 补充说明
    The biological activity of this product was determined by its inhibitory effect of IL-8 production in human PBMC by Human sTRAIL/Apo2L. 95% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 100ng/ml of sTRAIL Receptor-1.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    RECONSTITUTE with 60ul sterile WATER.

常规信息

  • 别名
    • Apo2
    • CD261
    • Cytotoxic TRAIL receptor
    • Death receptor 4
    • DR4
    • NF related apoptosis-inducing ligand receptor 1
    • TNF receptor superfamily member 10a
    • TNF-related apoptosis-inducing ligand receptor 1
    • TNFRSF10A
    • TR10A_HUMAN
    • TRAIL receptor 1
    • TRAIL-R1
    • TRAILR 1
    • TRAILR1
    • Tumor necrosis factor receptor superfamily member 10A
    • Tumor necrosis factor receptor superfamily member 10a variant 2
    • Tumor necrosis factor receptor superfamily, member 10a
    see all
  • 功能
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • 组织特异性
    Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • 序列相似性
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 细胞定位
    Membrane.
  • Information by UniProt

文献

ab641 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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