Recombinant人DR4 protein (ab56518)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • 种属Human
    • 氨基酸1 to 238

技术指标

Our Abpromise guarantee covers the use of ab56518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: PBS

  • 复溶Reconstitute with 50 µl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial. After reconsitution short term store at 4 °C, for long term storage store aliquoted at - 20 °C

常规信息

  • 别名
    • Apo2
    • CD261
    • Cytotoxic TRAIL receptor
    • Death receptor 4
    • DR4
    • NF related apoptosis-inducing ligand receptor 1
    • TNF receptor superfamily member 10a
    • TNF-related apoptosis-inducing ligand receptor 1
    • TNFRSF10A
    • TR10A_HUMAN
    • TRAIL receptor 1
    • TRAIL-R1
    • TRAILR 1
    • TRAILR1
    • Tumor necrosis factor receptor superfamily member 10A
    • Tumor necrosis factor receptor superfamily member 10a variant 2
    • Tumor necrosis factor receptor superfamily, member 10a
    see all
  • 功能Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • 组织特异性Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • 序列相似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human DR4 protein 图像

  • SDS Page analysis of ab56518; 12% separating gel; reducing conditions. Lane 1: 2 µg, Lane 2: 1 µg, Lane 3: 0.5 µg. Staining with Coomasie Blue.
  • ab56518 has a calculated molecular mass of 43 kDa. As a result of glycosylation, the recombinant protein migrates approximately as a 46 kDa protein in SDS-PAGE under reducing conditions. Immunostaining with DR4 specific antibody, detection with Goat anti-mouse / HRP secondary antibody. Gel: 12%. Lane 1 : ab56518 at 0.37 µg, Lane 2 : ab56518 at 0.15 µg, Lane 3 : ab56518 at 0.075 µg, Lane 4 : ab56518 at 0.037 µg, Lane 5 : ab56518 at 0.015 µg.

Recombinant Human DR4 protein (ab56518)参考文献

ab56518 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab56518.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"