Recombinant人DR1 protein (ab98246)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMASSSGNDDDLTIPRAAINKMIKETLPNVR VANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGF GSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKAR QQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
    • 分子量
      22 kDa including tags
    • 氨基酸
      1 to 176
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab98246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    >= 85 % SDS-PAGE.
    ab98246 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 0.1mM PMSF, pH 8.0

常规信息

  • 别名
    • Down regulator of transcription 1
    • Down regulator of transcription 1 TBP binding
    • Down-regulator of transcription 1
    • down-regulator of transcription 1, TBP-binding (negative cofactor 2)
    • DR 1
    • Dr1
    • Dr1 protein
    • NC 2
    • NC2
    • NC2 beta
    • NC2-beta
    • NC2B_HUMAN
    • Negative co factor 2
    • Negative cofactor 2
    • Negative cofactor 2 beta
    • Negative cofactor 2-beta
    • Protein Dr1
    • TATA binding protein associated phosphoprotein
    • TATA box/binding protein associated phosphoprotein DR1
    • TATA-binding protein-associated phosphoprotein
    see all
  • 功能
    The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • 序列相似性
    Belongs to the NC2 beta/DR1 family.
    Contains 1 histone-fold domain.
  • 翻译后修饰
    Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3µg ab98246

文献

ab98246 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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