Recombinant人DPYD protein (ab114585)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ12882
    • 种属Human
    • 序列MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSF ITSIANKNYY
    • 分子量38 kDa including tags
    • 氨基酸1 to 110

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技术指标

Our Abpromise guarantee covers the use of ab114585 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DHP
    • DHPDHase
    • Dihydropyrimidine dehydrogenase
    • Dihydropyrimidine dehydrogenase [NADP(+)]
    • Dihydropyrimidine dehydrogenase [NADP+]
    • Dihydrothymine dehydrogenase
    • Dihydrouracil dehydrogenase
    • DPD
    • DPYD
    • DPYD_HUMAN
    • MGC132008
    • MGC70799
    • OTTHUMP00000058954
    see all
  • 功能Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • 组织特异性Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • 通路Amino-acid biosynthesis; beta-alanine biosynthesis.
  • 疾病相关Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • 序列相似性Belongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human DPYD protein 图像

  • 12.5% SDS-PAGE showing ab114585 at approximately 37.73kDa stained with Coomassie Blue.

Recombinant Human DPYD protein (ab114585)参考文献

ab114585 has not yet been referenced specifically in any publications.

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