Recombinant人DPP2 protein (ab79660)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      26 to 492

技术指标

Our Abpromise guarantee covers the use of ab79660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Specific Activity: 1882 pmol/min/µg.
  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 130mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Dipeptidyl aminopeptidase II
    • Dipeptidyl peptidase 7
    • Dipeptidyl peptidase II
    • DPP II
    • DPP2
    • DPP7
    • DPPII
    • QPP
    • Quiescent cell proline dipeptidase
    • Weakly similar to LYSOSOMAL PRO X CARBOXYPEPTIDASE
    see all
  • 相关性
    DPP2 is a serine protease found most abundantly in the lysosome. There is also a non-lysosomal membrane-associated form of DPP2 reported in the rat brain (DPP-II-M), and a soluble form (DPP-II-S). First discovered as an enzyme involved in the terminal steps of protein degradation, and later as an enzyme involved in cell growth and quiescence, DPP2 cleaves N-terminal dipeptides and tripeptides from proteins. DPP2 has a preference for proline in the P1 position, and processes the tripeptides generated by DPP1 (which is unable to cleave if proline is in the P1 position). Some tumor cell lines express elevated DPP2 levels, and serum levels of DPP2 are elevated in some cancer patients, making DPP2 a potential tumor marker. DPP2 levels have been also been reported to be elevated in the cerebral spinal fluid from Parkinson’s patients.
  • 细胞定位
    Lysosome. Cytoplasmic vesicle. Secreted.

图片

  • Specific Activity 1882 pmol/min/µg. Determined using 20 µM Ala-Pro-AMC substrate.
  • SDS-PAGE showing ab79660 at approximately 52.5kDa (4µg).

文献

ab79660 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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