Recombinant人Dopamine beta Hydroxylase protein (ab114262)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP09172
    • 种属Human
    • 序列DAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYS FAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGP TVVSIGGGKG
    • 分子量38 kDa including tags
    • 氨基酸494 to 603

技术指标

Our Abpromise guarantee covers the use of ab114262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • dbh
    • DBM
    • Dopamine beta hydroxylase
    • Dopamine beta monooxygenase
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
    • Dopamine beta-monooxygenase
    • DOPO_HUMAN
    • OTTHUMP00000022501
    • Soluble dopamine beta-hydroxylase
    see all
  • 功能Conversion of dopamine to noradrenaline.
  • 通路Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • 疾病相关Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • 序列相似性Belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • 细胞定位Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt

Recombinant Human Dopamine beta Hydroxylase protein 图像

  • ab114262 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human Dopamine beta Hydroxylase protein (ab114262)参考文献

ab114262 has not yet been referenced specifically in any publications.

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