相关性DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.
细胞定位Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
Recombinant Human DOCK7 protein 图像
SDS-PAGE - DOCK7 protein (Tagged-His Tag) (ab92221)
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
Recombinant Human DOCK7 protein (ab92221)参考文献
has not yet been referenced specifically in any publications.