Recombinant人DOCK1 protein (ab114754)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MRIGRQSCKIHNYAINNGLFFKCMISPPSGDVRNDIYVTLVQGDFDKGSK TTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWF ETVKVLFTWSFYHMALIMKCSFVTQGNILTSSSARELLQAGRVSPNKVIQ GC
    • 分子量
      43 kDa including tags
    • 氨基酸
      1 to 152

技术指标

Our Abpromise guarantee covers the use of ab114754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/ul.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 180 kDa protein downstream of CRK
    • Ced5
    • Dedicator of Cytokinesis 1
    • Dedicator of cytokinesis protein 1
    • DOCK 1
    • DOCK 180
    • DOCK1
    • DOCK1_HUMAN
    • DOCK180
    see all
  • 功能
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
  • 组织特异性
    Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
  • 序列相似性
    Belongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • 结构域
    The DHR-2 domain is necessary and sufficient for the GEF activity.
  • 细胞定位
    Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE Stained with Coomassie Blue showing ab114754 at approximately 42.79kDa.

文献

ab114754 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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