Recombinant人DNAJC19 protein (ab104153)

概述

  • 产品名称Recombinant人DNAJC19 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ96DA6
    • 种属Human
    • 序列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGRY VLQAMKHMEP QVKQVFQSLP KSAFSGGYYR GGFEPKMTKR EAALILGVSP TANKGKIRDA HRRIMLLNHP DKGGSPYIAA KINEAKDLLE GQAKK
    • 分子量15 kDa including tags
    • 氨基酸19 to 116
    • 标签His tag N-Terminus , DDDDK tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab104153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • DnaJ (Hsp40) homolog, subfamily C, member 19
    • DnaJ homolog subfamily C member 19
    • DNAJC19
    • homolog of yeast TIM14
    • Mitochondrial import inner membrane translocase subunit TIM14
    • PAM18
    • TIM 14
    • TIM14
    • TIM14_HUMAN
    • TIMM 14
    • TIMM14
    • translocase of the inner mitochondrial membrane 14
    • Translocase of the inner mitochondrial membrane 14, yeast homolog of
    see all
  • 功能Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Defects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5) [MIM:610198]; also known as dilated cardiomyopathy with ataxia (DCMA). MGA5 is an autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure, and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid.
  • 序列相似性Belongs to the TIM14 family.
    Contains 1 J domain.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt

Recombinant Human DNAJC19 protein 图像

  • 15% SDS-PAGE, 3ug of ab104153 loaded

Recombinant Human DNAJC19 protein (ab104153)参考文献

ab104153 has not yet been referenced specifically in any publications.

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