Recombinant人DNAJB6 protein (ab105132)

概述

  • 产品名称Recombinant人DNAJB6 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO75190
    • 种属Human
    • 序列ab105132 is purified using conventional chromatography techniques.
    • 分子量39 kDa including tags
    • 氨基酸1 to 326
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab105132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 85 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • DJ4
    • DnaJ
    • DnaJ (Hsp40) homolog subfamily B member 6
    • DNAJ B6
    • DnaJ homolog subfamily B member 6
    • DnaJ like 2 protein
    • DNAJB6
    • DNJB6_HUMAN
    • Heat shock protein J2
    • HHDJ1
    • HSJ-2
    • HSJ2
    • LGMD1E
    • MRJ
    • MSJ-1
    • MSJ1
    see all
  • 功能Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
  • 组织特异性Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
  • 疾病相关Limb-girdle muscular dystrophy 1E
  • 序列相似性Contains 1 J domain.
  • 结构域The antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.
  • 细胞定位Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
  • Information by UniProt

Recombinant Human DNAJB6 protein 图像

  • 15% SDS-PAGE showing ab105132 (3 µg) at approximately 38.5 kDa.

Recombinant Human DNAJB6 protein (ab105132)参考文献

ab105132 has not yet been referenced specifically in any publications.

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