Recombinant人Dishevelled / Dvl1 protein (ab116823)

概述

  • 产品名称
    Recombinant人Dishevelled / Dvl1 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFK SMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHT DLPPPLERTG
    • 分子量
      38 kDa including tags
    • 氨基酸
      1 to 110

技术指标

Our Abpromise guarantee covers the use of ab116823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Dishevelled
    • Dishevelled 1
    • dishevelled 1 like
    • Dishevelled dsh homolog 1
    • Dishevelled-1
    • Dishevelled1
    • DSH homolog 1
    • Dvl
    • Dvl 1
    • Dvl1
    • DVL1_HUMAN
    • DVL1L1
    • MGC54245
    • Segment polarity protein dishevelled homolog DVL 1
    • segment polarity protein dishevelled homolog DVL 1 like
    • Segment polarity protein dishevelled homolog DVL-1
    • Segment polarity protein dishevelled homolog DVL1
    see all
  • 功能
    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
  • 疾病相关
    Robinow syndrome, autosomal dominant 2
  • 序列相似性
    Belongs to the DSH family.
    Contains 1 DEP domain.
    Contains 1 DIX domain.
    Contains 1 PDZ (DHR) domain.
  • 结构域
    The DIX domain promotes homooligomerization.
    The DEP domain mediates interaction with the cell membrane.
  • 翻译后修饰
    Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
  • 细胞定位
    Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116823

文献

ab116823 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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