short chain dehydrogenase/reductase family 9C, member 4
Short chain dehydrogenase/reductase retSDR8
Short-chain dehydrogenase/reductase retSDR8
功能3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.
组织特异性Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.
序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
细胞定位Microsome membrane. Endoplasmic reticulum membrane. Associated with microsomal membranes.