Recombinant人delta Sarcoglycan protein (ab116758)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      ILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAER LRVLGAEGTVFPKSIETPNVRADPFK
    • 分子量
      34 kDa
    • 氨基酸
      113 to 188

技术指标

Our Abpromise guarantee covers the use of ab116758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • 35 kDa dystrophin associated glycoprotein
    • 35 kDa dystrophin-associated glycoprotein
    • 35DAG
    • CMD1L
    • DAGD
    • Delta-sarcoglycan
    • Delta-SG
    • Dystrophin associated glycoprotein delta sarcoglycan
    • LGMD2F
    • MGC22567
    • Placental delta sarcoglycan
    • Sarcoglycan delta (35 kDa dystrophin associated glycoprotein)
    • SG delta
    • SGCD
    • SGCD_HUMAN
    • SGCDP
    • SGD
    see all
  • 功能
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 组织特异性
    Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.
  • 疾病相关
    Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F) [MIM:601287]. LGMD2F is an autosomal recessive disorder.
    Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L) [MIM:606685]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性
    Belongs to the sarcoglycan beta/delta/gamma/zeta family.
  • 翻译后修饰
    Glycosylated.
    Disulfide bonds are present.
  • 细胞定位
    Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human delta Sarcoglycan protein 图像

  • 12.5% SDS-PAGE analysis of ab116758 at approximately 33.99kDa, stained with Coomassie Blue.

Recombinant Human delta Sarcoglycan protein (ab116758)参考文献

ab116758 has not yet been referenced specifically in any publications.

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