The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. ab114472 is best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
Cadherin associated Src substrate
Cadherin-associated Src substrate
Catenin (cadherin associated protein) delta 1
Catenin delta 1
功能Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
组织特异性Expressed in vascular endothelium.
序列相似性Belongs to the beta-catenin family. Contains 10 ARM repeats.
结构域A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
翻译后修饰Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
细胞定位Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.