Recombinant人Cytokeratin 4 protein (ab114428)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP19013
    • 种属Human
    • 序列SSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEE EINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAE LSQMQTH
    • 分子量37 kDa including tags
    • 氨基酸194 to 300

技术指标

Our Abpromise guarantee covers the use of ab114428 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CK 4
    • CK-4
    • CK4
    • CYK4
    • Cytokeratin 4
    • Cytokeratin-4
    • Cytokeratin4
    • FLJ31692
    • K2C4_HUMAN
    • K4
    • Keratin
    • Keratin 4
    • Keratin type II cytoskeletal 4
    • Keratin-4
    • Keratin4
    • KRT 4
    • Krt4
    • type II cytoskeletal 4
    • Type-II keratin Kb4
    see all
  • 组织特异性Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
  • 疾病相关Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
  • 序列相似性Belongs to the intermediate filament family.
  • Information by UniProt

Recombinant Human Cytokeratin 4 protein 图像

  • ab114428 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Cytokeratin 4 protein (ab114428)参考文献

ab114428 has not yet been referenced specifically in any publications.

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