Recombinant人Cytokeratin 10 protein (ab114223)

概述

  • 产品名称Recombinant人Cytokeratin 10 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP13645
    • 种属Human
    • 序列KELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLA ETEGRYCVQLSQIQAQISALEEQLQ QIRAETECQNTEYQQLLDIKIRL ENEIQTYRSLLE
    • 分子量38 kDa including tags
    • 氨基酸345 to 454

技术指标

Our Abpromise guarantee covers the use of ab114223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BCIE
    • BIE
    • CK 10
    • CK-10
    • Cytokeratin-10
    • EHK
    • K10
    • K1C10_HUMAN
    • Keratin
    • Keratin 10
    • Keratin type i cytoskeletal 10
    • Keratin type I cytoskeletal 59 kDa
    • Keratin-10
    • Keratin10
    • KPP
    • KRT10
    • type I cytoskeletal 10
    see all
  • 组织特异性Seen in all suprabasal cell layers including stratum corneum.
  • 疾病相关Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
    Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
  • 序列相似性Belongs to the intermediate filament family.
  • Information by UniProt

Recombinant Human Cytokeratin 10 protein 图像

  • ab114223 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Cytokeratin 10 protein (ab114223)参考文献

ab114223 has not yet been referenced specifically in any publications.

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