The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性useful for Antibody Production and Protein Array
补充说明useful for Antibody Production and Protein Array
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl Note: Glutathione is reduced
NADPH Cytochrome P450 Reductase
NADPH dependent cytochrome P450 reductase
NADPH--cytochrome P450 reductase
P450 (cytochrome) oxidoreductase
P450 Cytochrome Oxidoreductase
功能This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
疾病相关Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome. Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].
序列相似性In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Contains 1 FAD-binding FR-type domain. Contains 1 flavodoxin-like domain.
细胞定位Endoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region.