Recombinant人Cytochrome P450 Reductase protein (ab112344)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MINMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKK KEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANR LSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTD NAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGA QRIFELGLGDDDGNLEEDFITWREQFWLAVCEHFGVEATGEESSIRQYEL VVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMS LNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPS EQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCEL LPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAK EPVGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQER AWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR EQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIV AELGAMEHAQAVDYIKKLMTKGRYSLDVWS
    • 分子量
      101 kDa including tags
    • 氨基酸
      1 to 680
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

常规信息

  • 别名
    • CPR
    • CYPOR
    • Cytochrome p450 oxidoreductase
    • DKFZp686G04235
    • FLJ26468
    • NADPH Cytochrome P450 Reductase
    • NADPH dependent cytochrome P450 reductase
    • NADPH--cytochrome P450 reductase
    • NCPR_HUMAN
    • P450 (cytochrome) oxidoreductase
    • P450 Cytochrome Oxidoreductase
    • P450R
    • por
    see all
  • 功能
    This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
  • 疾病相关
    Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
    Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].
  • 序列相似性
    In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.
  • 细胞定位
    Endoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab112344 at approximately 100.87kDa stained with Coomassie Blue.

文献

ab112344 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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