Recombinant人Cytochrome P450 2D6 protein (ab73434)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 分子量56 kDa
    • 额外的序列信息ytochrome P450 2D6 Human Recombinant (also called liver/kidney microsomal antigen 1) produced in SF9, is a glycosylated, polypeptide chain having a molecular mass of 55,801 Dalton.

技术指标

Our Abpromise guarantee covers the use of ab73434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab73434 reacts with autoimmune hepatitis patient sera.
  • 应用

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明


    This protein is suitable for biotinylation and iodination.

    ab73434 reacts with autoimmune hepatitis patient sera.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 400mM Sodium chloride, 16mM Sodium phosphate buffer, 0.08mM Potassium iodide, pH 7.6

常规信息

  • 别名
    • CPD6
    • CYP2D
    • CYP2D6
    • CYP2D7AP
    • CYP2D7BP
    • CYP2D7P2
    • CYP2D8P2
    • CYP2DL1
    • CYPIID6
    • Cytochrome P450 DB1
    • Cytochrome P450 family 2 subfamily D polypeptide 6
    • Debrisoquine 4 hydroxylase
    • Flavoprotein linked monooxygenase
    • Microsomal monooxygenase
    • P450 DB1
    • P450C2D
    • P450DB1
    • Xenobiotic monooxygenase
    see all
  • 相关性Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • 细胞定位Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Recombinant Human Cytochrome P450 2D6 protein (ab73434)参考文献

ab73434 has not yet been referenced specifically in any publications.

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