重组人Cytochrome P450 2D6蛋白(ab152317)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLR NLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLT
    • 分子量
      37 kDa including tags
    • 氨基酸
      91 to 190

相关产品

技术指标

Our Abpromise guarantee covers the use of ab152317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CPD6
    • CYP2D
    • CYP2D6
    • CYP2D7AP
    • CYP2D7BP
    • CYP2D7P2
    • CYP2D8P2
    • CYP2DL1
    • CYPIID6
    • Cytochrome P450 DB1
    • Cytochrome P450 family 2 subfamily D member 6
    • Cytochrome P450 family 2 subfamily D polypeptide 6
    • Debrisoquine 4 hydroxylase
    • Flavoprotein linked monooxygenase
    • Microsomal monooxygenase
    • P450 DB1
    • P450C2D
    • P450DB1
    • Xenobiotic monooxygenase
    see all
  • 相关性
    Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • 细胞定位
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

图片

  • 12.5% SDS-PAGE analysis of ab152317 stained with Coomassie Blue.

文献

ab152317 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab152317.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册