Cytochrome P450 family 24 subfamily A polypeptide 1
Cytochrome P450 subfamily XXIV
Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
Exo mitochondrial protein
Vitamin D 24 hydroxylase
Vitamin D(3) 24 hydroxylase
Vitamin D(3) 24-hydroxylase
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.