重组人CYP11A1蛋白(ab152319)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      KTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQ CLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTF WPFNQEATQQ
    • 分子量
      38 kDa including tags
    • 氨基酸
      412 to 521

技术指标

Our Abpromise guarantee covers the use of ab152319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Cholesterol 20 22 desmolase
    • Cholesterol desmolase
    • Cholesterol monooxygenase (side chain cleaving)
    • Cholesterol side chain cleavage enzyme
    • Cholesterol side chain cleavage enzyme mitochondrial
    • Cholesterol side-chain cleavage enzyme
    • CP11A_HUMAN
    • CYP11A
    • CYP11A1
    • CYPXIA1
    • Cytochrome P450 11A1
    • Cytochrome P450 11A1 mitochondrial
    • Cytochrome P450 family 11 subfamily A polypeptide 1
    • Cytochrome P450 subfamily XIA
    • Cytochrome P450(scc)
    • Cytochrome P450C11A1
    • mitochondrial
    • P450SCC
    • Steroid 20 22 lyase
    see all
  • 功能
    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
  • 通路
    Lipid metabolism; C21-steroid hormone metabolism.
  • 疾病相关
    Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).
    Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.
  • 序列相似性
    Belongs to the cytochrome P450 family.
  • 细胞定位
    Mitochondrion membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152319 stained with Coomassie Blue.

文献

ab152319 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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