Recombinant人CYB5R3 protein (ab119468)

概述

  • 产品名称Recombinant人CYB5R3 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP00387
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMFQRST PAITLESPDI KYPLRLIDRE IISHDTRRFR FALPSPQHIL GLPVGQHIYL SARIDGNLVV RPYTPISSDD DKGFVDLVIK VYFKDTHPKF PAGGKMSQYL ESMQIGDTIE FRGPSGLLVY QGKGKFAIRP DKKSNPIIRT VKSVGMIAGG TGITPMLQVI RAIMKDPDDH TVCHLLFANQ TEKDILLRPE LEELRNKHSA RFKLWYTLDR APEAWDYGQG FVNEEMIRDH LPPPEEEPLV LMCGPPPMIQ YACLPNLDHV GHPTERCFVF
    • 分子量34 kDa including tags
    • 氨基酸27 to 301
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab119468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab119468 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • B5R
    • Cyb5r3
    • Cytochrome b5 reductase
    • Cytochrome b5 reductase 3
    • DIA1
    • Diaphorase 1
    • Diaphorase-1
    • NADH cytochrome b5 reductase 3
    • NADH-cytochrome b5 reductase 3 membrane-bound form
    • NADH-cytochrome b5 reductase 3 soluble form
    • NB5R3_HUMAN
    • OTTHUMP00000028761
    • OTTHUMP00000198435
    • OTTHUMP00000198574
    • OTTHUMP00000198662
    • OTTHUMP00000198665
    see all
  • 功能Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
  • 组织特异性Isoform 2 is expressed at late stages of erythroid maturation.
  • 疾病相关Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:250800]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
  • 序列相似性Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
  • 细胞定位Endoplasmic reticulum membrane. Mitochondrion outer membrane and Cytoplasm. Produces the soluble form found in erythrocytes.
  • Information by UniProt

Recombinant Human CYB5R3 protein 图像

  • 15% SDS-PAGE analysis of ab119468 (3µg)

Recombinant Human CYB5R3 protein (ab119468)参考文献

ab119468 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119468.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"