Recombinant人CTRP5 protein (ab109041)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9BXJ0
    • 种属Human
    • 分子量26 kDa including tags
    • 氨基酸16 to 243
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab109041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Activates AMPK signaling pathway in rat L6 myoblasts.
  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平< 1.000 Eu/µg
  • 纯度> 90 % SDS-PAGE.
    ab109041 was 0.2µm filtered
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Reconstitute in distilled water

常规信息

  • 别名
    • C1q and tumor necrosis factor related protein 5
    • C1QTNF5
    • Complement C1q tumor necrosis factor related protein 5 precursor
    • LORD
  • 相关性Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP5 has been suggested to be involved in age-related macular degeneration.
  • 细胞定位Secreted

Recombinant human CTRP5 protein 图像

  • ab109041 activates AMPK signaling pathway in rat L6 myoblasts.
    Differentiated rat L6 myoblasts were stimulated with control buffer or 0.5µg/ml ab109041 for 30min. The cell lysate was subjected to immunoblotting with antibodies against pAMPK and total AMPK.

Recombinant human CTRP5 protein (ab109041)参考文献

ab109041 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"