Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1
NLI interacting factor 3
NLI-interacting factor 3
Nuclear LIM interactor interacting factor 3
Nuclear LIM interactor-interacting factor 3
Small C-terminal domain phosphatase 1
Small CTD phosphatase 1
功能Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
组织特异性Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.