Recombinant人CTDSP1 protein (ab124856)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMDSSAVITQISKEEARGPLRGKGDQKSAAS QKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLP EAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLK RPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESC VFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSD TELHDLLPFFEQLSRVDDVYSVLRQPRPGS
    • 分子量
      31 kDa including tags
    • 氨基酸
      1 to 260
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.
    ab124856 is purified by proprietary chromatographic techniques and sterile filtered.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1
    • Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
    • CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1
    • CTD small phosphatase 1
    • CTDS1_HUMAN
    • CTDSP1
    • NIF3
    • NLI IF
    • NLI interacting factor 3
    • NLI-IF
    • NLI-interacting factor 3
    • NLIIF
    • Nuclear LIM interactor interacting factor 3
    • Nuclear LIM interactor-interacting factor 3
    • SCP1
    • Small C-terminal domain phosphatase 1
    • Small CTD phosphatase 1
    see all
  • 功能
    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
  • 组织特异性
    Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
  • 序列相似性
    Contains 1 FCP1 homology domain.
  • 细胞定位
    Nucleus. Colocalizes with RNA polymerase II.
  • Information by UniProt

文献

ab124856 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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